Discover how scientists engineered polyketide synthases through domain substitution to create novel antibiotic precursors like 2-Nor-6-deoxyerythronolide B.
Explore how evolutionary biology shapes thioesterase enzymes in polyketide synthesis and their implications for drug discovery and sustainable manufacturing.
Discover how oxetane-based polyketide surrogates are revolutionizing our understanding of polyketide synthases and accelerating drug discovery.
Discover the groundbreaking research revealing hidden flexibility in type II polyketide synthases and its implications for medicine and synthetic biology.