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Research Articles

Engineering Nature's Assembly Line: How Scientists Rewired a Molecular Factory to Create New Antibiotics

Discover how scientists engineered polyketide synthases through domain substitution to create novel antibiotic precursors like 2-Nor-6-deoxyerythronolide B.

Zoe Hayes
Nov 01, 2025

Nature's Molecular Architects: How Evolution Shapes Medicine-Making Enzymes

Explore how evolutionary biology shapes thioesterase enzymes in polyketide synthesis and their implications for drug discovery and sustainable manufacturing.

Dylan Peterson
Oct 30, 2025

The Molecular Decoy: How a Simple Chemical Trick Revealed Nature's Drug Factory Secrets

Discover how oxetane-based polyketide surrogates are revolutionizing our understanding of polyketide synthases and accelerating drug discovery.

Lucas Price
Oct 26, 2025

Nature's Hidden Blueprint: The Unexpected Mechanism Behind Benzopyrone Formation

Discover the groundbreaking research revealing hidden flexibility in type II polyketide synthases and its implications for medicine and synthetic biology.

Dylan Peterson
Oct 18, 2025

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